Chronic Diabetes Followed by Chronic Cerebral Ischemia Induced by Bilateral Carotid Artery Ligation in Arteriosclerotic Versus Nonarteriosclerotic Rats

ثبت نشده
چکیده

Chronic Diabetes Followed by Chronic Cerebral Ischemia Induced by Bilateral Carotid Artery Ligation in A rleriosclerotic Versus Nonarteriosclerotic Rats • Male and female, arteriosclerotic (breeder) and nonarteriosclerotic (virgin), SpragueDawley rats were made severely diabetic with alloxan. Two weeks later experimental animals had both carotid arteries ligated to induce a state of acute cerebral ischemia. After six weeks of cerebral ischemia either with or without severe diabetes the animals were killed. Animals which survived either the acute induction of diabetes or cerebral ischemia did not manifest any new episodes of cerebral ischemia. Subjects with combined diabetes and cerebral ischemia manifested the greatest loss in body weight, adrenal hypertrophy and thymus gland involution, increased levels of serum CPK and SGOT, but decreased SGPT and LDH, hyperglycemia and hypertriglyceridemia, and the most extensive cerebral edema. It is suggested that diabetic rats may have a greater predilection toward cerebrovascular accidents because the diabetic state contributes not only to an exacerbation of atherosclerosis, but also complicates any condition of cerebrovascular ischemia by creating extracerebral edema. Additional

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chronic diabetes followed by chronic cerebral ischemia induced by bilateral carotid artery ligation in arteriosclerotic versus nonarteriosclerotic rats.

Male and female, arteriosclerotic (breeder) and nonarteriosclerotic (virgin), Sprague-Dawley rats were made severely diabetic with alloxan. Two weeks later experimental animals had both carotid arteries ligated to induce a state of acute cerebral ischemia. After six weeks of cerebral ischemia either with or without severe diabetes the animals were killed. Animals which survived either the acute...

متن کامل

Metabolic changes in response to acute cerebral ischemia following bilateral carotid artery ligation in arteriosclerotic versus nonarteriosclerotic rats.

Metabolic Changes in Response to Acute Cerebral Ischemia Following Bilateral Carotid Artery Ligation in A rteriosclerotic Versus Nonarteriosclerotic Rats • Both the left and right carotid arteries of arteriosclerotic and nonarteriosclerotic male and female rats were surgically ligated to induce a state of sudden and severe cerebral ischemia. The animals promptly developed signs of cerebral impa...

متن کامل

Metabolic Changes in Response to Acute Cerebral Ischemia Following Unilateral Carotid Artery Ligation in Arteriosclerotic Versus Nonarteriosclerotic Rats

Metabolic Changes in Response to Acute Cerebral Ischemia Following Unilateral Carotid Artery Ligation in A rteriosclerotic Versus Nonarteriosclerotic Rats • The left carotid artery of arteriosclerotic and nonarteriosclerotic male and female rats was surgically ligated to induce a state of cerebral ischemia. The animals promptly developed signs of cerebral impairment and were sacrificed 2, 4, 6,...

متن کامل

Hemodynamic Components of a Cardiogenic Hypertensive Chemoreflex in Dogs

corticosterone in male and female virgin and breeder rats. Acta Endocrinol 62: 411-424, 1969 14. lams SG, Wexler BC: Aldosterone, deoxycorticosterone and corticosterone differences between arteriosclerotic breeder vs nonarteriosclerotic virgin rats. Atherosclerosis 24: 63-73, 1976 15. Wexler BC, True CW: Carotid and cerebral arteriosclerosis. Circ Res 12: 659-666, 1963 16. Wexler BC: Spontaneou...

متن کامل

Hemodynamic Components of a Cardiogenic Hypertensive Chemoreflex in Dogs

corticosterone in male and female virgin and breeder rats. Acta Endocrinol 62: 411-424, 1969 14. lams SG, Wexler BC: Aldosterone, deoxycorticosterone and corticosterone differences between arteriosclerotic breeder vs nonarteriosclerotic virgin rats. Atherosclerosis 24: 63-73, 1976 15. Wexler BC, True CW: Carotid and cerebral arteriosclerosis. Circ Res 12: 659-666, 1963 16. Wexler BC: Spontaneou...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005